Herbicidal nucleosides from microbial sources.

Discovering new bioactive molecules from microbial sources

There is an increased need for new drug leads to treat diseases in humans, animals and plants. A dramatic example is represented by the need for novel and more effective antibiotics to combat multidrug-resistant microbial pathogens. Natural products represent a major source of approved drugs and still play an important role in supplying chemical diversity, despite a decreased interest by large ...

Carbohydrates from Biomass: Sources and Transformation by Microbial Enzymes

a-Amylases from Microbial Sources – An Overview on Recent Developments

This review covers the progress made in research on microbial a-amylase, a highly demanded industrial enzyme in various sectors such as food, pharmaceuticals, textiles, detergents, etc. Amylases are of ubiquitous occurrence and hold the maximum market share of enzyme sales. The article surveys the a-amylase family and the major characteristics, microbial sources, production aspects, downstream ...

Triazines Herbicidal Assessed Activity

Correlation coefficients and associated squared values are used as assessment parameters in validation of structure-activity relationships. Seven correlation coefficients were calculated for models that characterized the relationship between chemical structure the herbicidal activity of a triazine analogues series. Three previously reported models were compared by using Pearson (rPrs), Spearman...

Hypoxanthine production from nucleosides in erythrocyte ghosts.

A primary event in the metabolism of nucleosides by human erythrocytes involves the action of a nucleoside phosphorylase (l-3). In the presence of arsenate, free ribose is produced from adenosine, inosine, guanosine, and xanthosine (4). Adenosine has been reported to be converted to adenine (4), but other studies have shown that adenosine was converted by deamination to inosine and then cleaved...